In Kozhikode, amidst the heightened scrutiny in Malappuram district following a Nipah infection fatality, a resident of Othayi in Edavanna panchayat has been admitted to Manjeri Government Medical College Hospital with suspected symptoms of Mpox, a viral illness caused by the monkeypox virus. The 38-year-old individual, who recently returned from Dubai, sought medical help at the dermatology outpatient department at the medical college after experiencing fever and skin rashes. Based on his symptoms and travel history, doctors decided to admit him for observation. Samples have been sent to the virology lab at Kozhikode Government Medical College Hospital for testing, with PCR results expected by Wednesday evening. Health Minister Veena George confirmed the case and noted that the patient had taken precautions upon developing symptoms, isolating himself from his family. The District Medical Officer, Dr. R Renuka, advised close relatives to remain vigilant as the patient displayed symptoms upon returning home. Despite the World Health Organization declaring Mpox a public health emergency of international concern due to a new strain of the virus, known as Clade 1, there have been no confirmed cases of this strain in India. The recent case reported in Haryana was linked to the West African Clade 2 virus, similar to previously reported cases in India since 2002.The current public health emergency concerning Clade 1 of Mpox, reported by the WHO, is linked to Monkeypox, which is caused by the Monkeypox virus (MPXV). MPXV is a double-stranded DNA virus that belongs to the Orthopoxvirus genus in the Poxviridae family. There are two main groups of the virus: Clade I (including subclades 1a and 1b) and Clade 2 (comprising subclades 2a and 2b). Mpox can spread through close contact with an infected individual, contaminated objects, or infected animals. Common symptoms of Mpox include rashes, fever, sore throat, headache, muscle aches, and swollen lymph nodes.